In the laboratory, our research focuses on the regulation of DNA replication, genome stability, and the chromatin response to DNA damage. We investigate how chromatin regulators influence the progression of replication forks and prevent conflicts between replication and transcription, which is crucial for maintaining genome integrity. Studies conducted by our team have demonstrated that INO80 is essential for the resolution of R-loops, which can hinder DNA replication and contribute to genomic instability in cancer cells.

We investigate the regulation of DNA repair processes, particularly double-strand break (DSB) repair mechanisms and ways to exploit these for therapeutic purposes.

A different facet investigates protein-drug interactions for targeted cancer therapy, focusing on lectins as carriers for cytotoxic compounds, such as metal-based anticancer drugs.