Publications
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2024
In silico exploration of 4(α-l-rhamnosyloxy)-benzyl isothiocyanate: A promising phytochemical-based drug discovery approach for combating multi-drug resistant Staphylococcus aureus
Soham Bhattacharya, Adrish Dutta, Pijush Kanti Khanra, Neha Gupta, Ritesh Dutta, Nikolay T. Tzvetkov, Luigi Milella, Maria Ponticelli
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2024
Crystal Structures, Molecular Docking and In Vitro Investigations of Two 4-Substituted 2-(5,5-dimethyl-3-styrylcyclohex-2-enylidene)malononitrile Derivatives as Potential Topoisomerase II Inhibitors
Martina I. Peeva, Maya G. Georgieva, Aneliya A. Balacheva, Maria Ponticelli, Ivan P. Bogdanov, Tsonko Kolev, Luigi Milella, Hans-Georg Stammler, Nikolay T. Tzvetkov
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2024
In Vitro Investigation of the Cytotoxic and Antiproliferative Effects of Haberlea rhodopensis Total Extract: A Comparative Study
Martina I. Peeva, G. Georgieva, Maya, Aneliya A. Balacheva, Atanas Pavlov, Nikolay T. Tzvetkov
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2024
Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review
Valentina Lerose, Maria Ponticelli, Nadia benedetto, Vittorio Carlucci, Ludovica Lela, Nikolay T. Tzvetkov, Luigi Milella
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2024
Natural product drug discovery and drug design: two approaches shaping new pharmaceutical development
Nikolay T. Tzvetkov, Kiril Kirilov, Maima Matin, Atanas G. Atanasov
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2024
Favipiravir vs. Deferiprone: Tautomeric, photophysical, in vitro biological studies, and binding interactions with SARS-Cov-2-MPro/ACE2
Nikolay T. Tzvetkov, Martina I. Peeva, Maya G. Georgieva, Vera Deneva, Aneliya A. Balacheva, Ivan P. Bogdanov, Maria Ponticelli, Luigi Milella, Kiril Kirilov, Maima Matin, Hans-Georg Stammler, Atanas G. Atanasov, Liudmil Antonov
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2023
An Insight into Citrus medica Linn.: A Systematic Review on Phytochemical Profile and Biological Activities
Nadia Benedetto, Vittorio Carlucci, Immacolata Faraone, Ludovica Lela, Maria Ponticelli, Daniela Russo, Claudia Mangieri, Nikolay T. Tzvetkov, Luigi Milella
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2023
Neurotensin (8–13) analogs as dual NTS1 and NTS2 receptor ligands with enhanced effects on a mouse model of Parkinson's disease
Toni Kühl, Maya G. Georgieva, Harald Hübner, Maria Lazarova, Matthias Vogel, Bodo Haas, Martina I. Peeva, Aneliya A. Balacheva, Ivan P. Bogdanov, Luigi Milella, Maria Ponticelli, Tsvetomir Garev, Immacolata Faraone, Roumyana Detcheva, Borislav Minchev, Polina Petkova-Kirova, Lyubka Tancheva, Reni Kalfin, Atanas G. Atanasov, Liudmil Antonov, Tamara I Pajpanova, Kiril Kirilov, Marcus Gastreich, Peter Gmeiner, Diana Imhof, Nikolay T. Tzvetkov
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2023
Cyanidin-3-O-glucoside as a Nutrigenomic Factor in Type 2 Diabetes and Its Prominent Impact on Health
Iga Bartel, Magdalena Koszarska, Nina Strzałkowska, Nikolay T. Tzvetkov, Dongdong, Wang, Jarosław O Horbańczuk, Agnieszka Wierzbicka, Atanas G. Atanasov, Artur Jóźwik
International Journal of Molecular Sciences 2023, 24(11), 9765
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2023
Bibliometric analysis and evidence of clinical efficacy and safety of digital pills
Olena Litvinova, Elisabeth Klager, Andy Wai Kan Yeung, Nikolay T. Tzvetkov, Oliver Kimberger, Maria Kletecka-Pulker, Harald Willschke, Atanas G. Atanasov
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2022
SR-BI as a target of natural products and its significance in cancer.
D. Wang, J. Huang, T. Gui, Y. Yang, T. Feng, N.T. Tzvetkov, T. Xu, Z. Gai, Y. Zhou, J. Zhang, A.G. Atanasov
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2022
Advances and challenges in cancer treatment and nutraceutical prevention: The possible role of dietary phenols in BRCA regulation
H. Khan, F. Labanca, H. Ullah, Y. Hussain, Nikolay T. Tzvetkov, E. K. Akkol, Luigi Milella
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2022
In silico identification of multi-target ligands as promising hit compounds for neurodegenerative diseases drug development
P. Alov, H. Stoimenov, I. Lessigiarska, T. Pencheva, NikolayT. Tzvetkov, I. Pajeva, I. Tsakovska
International Journal of Molecular Sciences, 2022, 23, 13650
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2022
Digital pills with ingestible sensors: Patent landscape analysis
O. Litvinova, E. Klager, Nikolay T. Tzvetkov, O. Kimberger, M. Kletecka-Pulker, H. Willschke, Atanas G. Atanasov
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2021
Advances and challenges in cancer treatment and nutraceutical prevention: the possible role of dietary phenols in BRCA regulation
Haroon Khan, Fabiana Labanca, Hammad Ullah, Yaseen Hussain, Nikolay T. Tzvetkov, Esra Küpeli Akkol, Luigi Milella
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2021
Natural products in drug discovery: Advances and opportunities
A.G. Atanasov, S.B. Zotchev, V.M. Dirsch, The International Natural Product Sciences Taskforce, N.T. Tzvetkov, C.T. Sapuran
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2021
Vascuprotective effects of ginger (Zingiber officinale Roscoe) and underlying molecular mechanisms
C. Li, J. Li, F. Jiang, N.T. Tzvetkov, J.O. Horbañczuk, Y. Li, A.G. Atanasov D. Wang
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2021
Reactive oxygen species and their impact in neurodegenerative diseases: Literature landscape analysis
A.W.K. Yeung, N.T. Tzvetkov, M.G. Georgieva, I.V. Ognyanov, K. Kordos, A. Jozwik, T. Kühl, G. Perry, M.C. Petralia, E. Mazzon, A.G. Atanasov
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2020
Preventive Effect of a Polyphenol-Rich Extract from Geranium sanguineum L. on Hepatic Drug Metabolism in Influenza Infected Mice
Silviya Abarova, Lyubka Tancheva, Rumen Nikolov, Julia Serkedjieva, Elitsa Pavlova, Alessia Bramanti, Ferdinando Nicoletti, Nikolay T. Tzvetkov
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2020
The ethnopharmacological literature: An analysis of the scientific landscape
Andy Wai Kan Yeung, Michael Heinrich, Anake Kijjoa, Nikolay T. Tzvetkov, Atanas G. Atanasov
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2020
Ethnopharmacological applications targeting alcohol abuse: overview and outlook
Laxman Singh, Tanuj Joshi, Devesh Tewari, Javier Echeverría, Andrei Mocan, Archana N Sah, Nikolay T. Tzvetkov, Zheng Feei Ma, Yeong Yeh Lee, Piotr Poznański, Mariusz Sacharczuk, Artur Jóźwik, Jarosław O Horbańczuk, Joanna Feder-Kubis, Atanas G. Atanasov
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2020
The significance of natural product derivatives and traditional medicine for COVID-19
D. Wang, J. Huang, A.W.K. Yeung, N.T. Tzvetkov, J.O. Horbañczuk, H. Willschke, Z. Gai, A.G. Atanasov
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2020
Lignans: Quantitative analysis of the research literature
A.W.K. Yeung, N.T. Tzvetkov, A.A. Balacheva, M.G. Georgieva, R.-Y. Gan, A. Jozwik, B. Pyzel, J.O. Horbañczuk, E. Novellino, A. Durazzo, M. Lucarini, E. Camilli, E.B. Souto, A.G. Atanasov, A. Santini
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2020
Neuroprotective mechanisms of three natural antioxidants on a rat model Parkinson´s disease: A comparative study
L.P. Tancheva, M.I. Lazarova, A.V. Alexandrova, S.T. Dragomanova, F. Nicoletti, E.R. Tzvetanova, Y.K. Hodzhev, R.E. Kalfin, S.A. Miteva, A. Santini, E. Mazzon, N.T. Tzvetkov, A.G. Atanasov
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2020
Neurotensins and their therapeutic potential: Research field study
A.W.K. Yeung, M.G. Georgieva, K. Kirilov, A.A. Balacheva, M.I. Peeva, O.K. Horbañczuk, J.O. Horbañczuk, M. Lucarini, A. Durazzo, A. Santini, E.B. Souto, T.I. Pajpanova, L. Milella, A.G. Atanasov, N.T. Tzvetkov
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2019
Current research in biotechnology: exploring the biotech forefront
Andy Wai Kan Yeung, Nikolay T. Tzvetkov, Vijai K Gupta, Subash C Gupta, Gorka Orive, Günther K Bonn, Bernd Fiebich, Anupam Bishayee, Thomas Efferth, Jianbo Xiao, Ana Sanches Silva, Gian Luigi Russo, Maria Daglia, Maurizio Battino, Ilkay Erdogan Orhan, Ferdinando Nicoletti, Michael Heinrich, Bharat Bhushan Aggarwal, Marc Diederich, Maciej Banach, Wolfram Weckwerth, Rudolf Bauer, George Perry, Edward A Bayer, Lukas A Huber, Jean-Luc Wolfender, Robert Verpoorte, Francisco A Macias, Michael Wink, Marc Stadler, Simon Gibbons, Alejandro Cifuentes, Elena Ibanez, Gérard Lizard, Rolf Müller, Michael Ristow, Atanas G. Atanasov
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2019
Molecular neuroscience at its “high”: bibliometric analysis of the most cited papers on endocannabinoid system, cannabis and cannabinoids
Andy Wai Kan Yeung, Nikolay T. Tzvetkov, Nicolas Arkells, Luigi Milella, Adrian M Stankiewicz, Łukasz Huminiecki, Olaf K Horbanczuk, Atanas G. Atanasov
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2019
Targeting foam cell formation in atherosclerosis: Therapeutic potential of natural products
D. Wang, Y. Yang, Y. Lei, N.T. Tzvetkov, Y. Liu, A.W.K Yeung, S. Xu, A.G. Atanasov
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2019
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholonesterase inhibitors
N.T. Tzvetkov, H.-G. Stammler, M.G. Georgieva, D. Russo, I. Faraone, A.A. Balacheva, S. Hristova, A.G. Atanasov, L. Milella, L. Antonov, M. Gastreich
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2019
(Pyrrolo-pyridin-5- yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons
N.T. Tzvetkov, H.-G. Stammler , S. Hristova, A.G. Atanasov, L. Antonov
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2019
Monoamine oxidases (MAOs) as privileged molecular targets in neuroscience: research literature analysis
A.W.K. Yeung, M. Georgieva, A.G. Atanasov, N.T. Tzvetkov
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2019
Antioxidants: scientific literature landscape
A.W.K. Yeung, N.T. Tzvetkov, O.S. El-Tawil, S.G. Bungau, M.M. Abdel-Daim, A.G. Atanasov
Oxidative Medicine and Cellular Longevity 2019, Article ID 8278454, 11 pages
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2018
Vasculoprotective Effects of Pomegranate (Punica granatum L.)
Dongdong Wang, Cigdem Özen, Ibrahim M Abu-Reidah, Sridevi Chigurupati, Jayanta Kumar Patra, Jarosław O. Horbanczuk, Artur Jóźwik, Nikolay T. Tzvetkov, Pavel Uhrin, Atanas G. Atanasov
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2018
Natural product-based multitarget ligands for Alzheimer’s disease treatment?
N.T. Tzvetkov, A.G. Atanasov
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2018
When neuroscience meets pharmacology: a neuropharmacology literature analysis
A.W.K. Yeung, N.T. Tzvetkov, A.G. Atanasov
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2018
Phytochemicals as potent modulatoes af autophagy for cancer therapy
M.A. Moosavi, A. Hghi, M. Rahmati, H. Taniguchi, A. Mocan, J. Echeverria, V.K.Gupta, N.T. Tzvetkov, A.G. Atanasov
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2018
Autophagy and Alzheimer’s disease: from molecular mechanisms to therapeutic implications
Md. Uddin, A. Stachowiak, A.A. Mamun, N.T. Tzvetkov, S. Takeda, A.G. Atanasov, L.B. Bergantin, M.M. Abdel-Daim, A.M. Stankiewicz
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2018
Ethnopharmacological approaches for dementia therapy and significance of natural products and herbal drugs
D. Tewari, A.M. Stankiewicz, A. Mocan, A.N. Sah, N.T. Tzvetkov, L. Huminiecki, J.O. Horbañczuk, A.G. Atanasov
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2018
Preventive efefct of two new neurotensin analogues on Parkinson’s disease rat model
M. Lazarova, A. Popatanasov, R. Klissurov, S. Stoeva, T. Pajpanova, R. Kalfin, L. Tancheva
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2018
Vascular smooth muscle cell proliferation as a therapeutic target. Part 2: Natural products inhibiting proliferation
P. Uhrin, D. Wang, A. Mocan, B. Waltenberger, J.M. Breuss, D. Tewari, J. Mihaly-Bison, L. Huminiecki, R.R. Starzyñski, N.T. Tzvetkov, J. Horbañczuk, A.G. Atanasov
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2018
Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: Molecular targets and pathways
P. Uhrin, D. Wang, A. Mocan, B. Waltenberger, J.M. Breuss, D. Tewari, J. Mihaly-Bison, L. Huminiecki, R.R. Starzyñski, N.T. Tzvetkov, J. Horbañczuk, A.G. Atanasov
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2017
Tautomerism of N-(3, 4-dichlorophenyl)-1H-indazole-5-carboxamide–A new selective, highly potent and reversible MAO-B inhibitor
Nikolay T. Tzvetkov, Hans-Georg Stammler, Liudmil Antonov
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2017
Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors
N.T. Tzvetkov, H.-G. Stammler, B. Neumann, S. Hristova, L. Antonov, M. Gastreich
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2017
Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration
Nikolay T. Tzvetkov, Liudmil Antonov
Journal of Enzyme Inhibition and Medicinal Chemistry 2017, 32(1), 960–967
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2016
A simple approach to multifunctionalized N1-alkylated 7-amino-6-azaoxindole derivatives using their in situ stabilized tautomer form
Nikolay T. Tzvetkov, Beate Neumann, Hans-Georg Stammler, Liudmil Antonov
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2014
nteraction of methionine – enkephalins with raft-forming lipids: monolayers and BAM experiments
A. Tsanova, A. Jordanova, T Dzimbova, T. Pajpanova, E. Golovinsky, Z. Lalchev
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2014
Kyotorphin analogues containing unnatural amino acids: synthesis, analgesic activity and computer modeling of their interactions with µ-receptor
T. Dzimbova, A. Bocheva, T. Pajpanova
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2014
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency
N.T. Tzvetkov, S. Hinz, P. Küppers, M. Gastreich, C.E. Müller
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2012
Facile synthesis of 5-amino-and 7-amino-6-azaoxindole derivatives
Nikolay T. Tzvetkov, Christa E. Müller
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2012
Regioselective synthesis of 7, 8-dihydroimidazo [5, 1-c][1, 2, 4] triazine-3, 6 (2H, 4H)-dione derivatives: A new drug-like heterocyclic scaffold
Nikolay T. Tzvetkov, Harald Euler, Christa E. Müller
Beilstein Journal of Organic Chemistry 2012, 8(1), 1584–1593