Program
DAY 1
20 October
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09:00–09:30 |
Registration |
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09:30–10:00 |
Opening Remarks |
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SESSION I | Mechanisms of Epigenetic Regulation • Chair: Prof. Stefan Dimitrov |
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10:00–10:40 |
Plenary Lecture: Epigenetic Regulation of Neurological Disorders: Role of Lysine Acetyltransferases p300/CBP - Prof. Tapas Kumar Kundu (Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), India) |
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10:40–11:10 |
Chromatin dynamics in host-microbiota crosstalk and intestinal biology — Prof. Patrick Varga-Weisz (University of Essex, UK) |
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11:10–11:40 |
Coffee Break & Networking |
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11:40–12:00 |
From genotype to gonadal fate: A functional validation of WT1 variants — Dr. Mehdi Totonchi (Institute of Molecular Biology, BAS, Bulgaria) |
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12:00–12:20 |
Analysis of the function of H2A.Z by using mini-auxin-inducible degron 2 (mAID2) technology — Assoc. Prof. Dimitar Iliev (Institute of Molecular Biology, BAS, Bulgaria) |
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12:20–12:35 |
Existence of an analytic expression for stationary total current of a single-cycle process as a starting point of analysis for various complex biological systems — Dr. Alexander G. Dimitrov (Institute of Biophysics and Biomedical Engineering, BAS, Bulgaria) |
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12:35–12:55 |
Effects of changes in chromatin structure on energy source utilization, nutrient sensing, and ageing — Penyo Ivanov (Institute of Molecular Biology, BAS, Bulgaria) |
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12:55–14:00 |
Lunch |
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SESSION II | New Horizons in Molecular Medicine • Chair: Assoc. Prof. Dimitar Iliev |
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14:00–14:30 |
From molecular diagnosis to integrated care: bridging the implementation gap in rare diseases- Prof. Rumen Stefanov (Medical University of Plovdiv, Bulgaria |
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14:30–15:00 |
DNA damage and innate immune responses in health and disease — Prof. George A. Garinis (University of Crete and IMBB-FORTH, Greece) |
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15:00–15:30 |
Oligogenism as a cause of human infertility — Prof. Christophe Arnoult (IAB Grenoble, France) |
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15:30–16:00 |
Coffee Break & Networking |
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16:00–16:30 |
Modeling rare diseases: the example of hereditary peripheral neuropathies- Prof. Albena Jodanova (VIB Center for Molecular Neurology, University of Antwerp, Belgium/ Medical University of Sofia (Bulgaria) |
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16:30–17:15 |
Panel Discussion: “Bridging the Gap: From Bench to Bedside in Rare Diseases and Epigenetics” |
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17:15–18:30 |
Poster Session |
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19:30 -23:30 |
Conference Dinner |
DAY 2
21 October
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SESSION III | Epigenetics in Rare Diseases • Chair: Prof. Iva Ugrinova |
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09:00–09:30 |
Genomic research in rare disorders — Prof. Julien Thévenon (Grenoble Alpes University Hospital, France) |
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09:30–10:00 |
Chromatinopathies: from altered genome structure to disease etiology- Prof. Stefan Dimitrov (Institute of Molecular Biology, BAS, Bulgaria) |
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10:00–10:30 |
Chromatin dynamics in health and disease — Dr. Seyit Kale (Izmir Biomedicine and Genome Center, Türkiye) |
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10:30–11:00 |
Imprinting disorders - or how the genes escape from the Mendel laws- Prof. Ivanka Dimova (Medical University, Sofia, Bulgaria) |
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11:00–11:30 |
Coffee Break & Networking |
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11:30–11:45 |
Epigenetic alterations in breast cancer: From molecular dysregulation to diagnostic, prognostic, and predictive biomarkers — Assoc. Prof. Lyudmila Belenska-Todorova (SU, St. Kliment Ohridski, Faculty of Medicine, Bulgaria) |
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11:45–12:05 |
The antagonistic regulation of gene transcription by the chromatin remodeler and co-activator Swi-Snf and the co-repressor Tup1-Cyc8 in yeast - Prof. Alastair Fleming (Trinity College Dublin, Ireland) |
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SESSION IV | Diagnostic Frontiers & Biomarkers • Chair: Assoc. Prof. Emil Parvanov |
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12:05–12:25 |
An automatic tracker for chromosome trajectories in mitotic and interphase chromosomes — Dr. Rumen Stamatov (Institute of Molecular Biology, BAS, Bulgaria) |
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12:25–12:40 |
The role of a differentiated approach in the screening and diagnosis of breast cancer in women with genetic mutations and rare diseases — Dr. Georgi Kesov, MD (Serdikamed Hospital, Sofia, Bulgaria |
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12:40–13:00 |
The role of a differentiated approach in the screening and diagnosis of breast cancer in women with genetic mutations and rare diseases — Dr. Georgi Kesov, MD (Serdikamed Hospital, Sofia, Bulgaria) |
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13:00–14:00 |
Lunch |
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14:00–14:20 |
From biomarkers to dynamic biological age: An AI-driven framework for personalized health monitoring — Dr. Nikolay Vassev, CEO of Epix AI, Bulgaria |
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SESSION V | Therapeutic Strategies & Drug Development • Chair: Dr. Mehdi Totonchi |
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14:40–15:10 |
Drugging epigenetic pathways to treat fungal infections — Prof. Jérôme Govin (Inserm and University of Grenoble) |
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15:10–15:30 |
From scientific discovery to patient access: The role of the pharmaceutical industry in rare disease innovation — Gogo Krastev (Country Lead, Genesis Pharma, Bulgaria) |
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15:30–16:00 |
Coffee Break |
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16:00–16:20 |
Neurotensin (8–13) analogs targeting NTS1 and NTS2 receptors — Prof. Nikolay T. Tzvetkov (Institute of Molecular Biology, BAS, Bulgaria) |
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16:40–17:00 |
Young Scientists Awards & Closing Ceremony |